Chopra, A., Lavin, P., Patwardhan, B., and Chitre, D. A 32-week randomized, placebo-controlled clinical evaluation of RA-11, an Ayurvedic drug, on osteoarthritis of the knees. J Clin Rheumatol. 2004;10(5):236-245. View abstract. Turmeric and curcumin are generally safe. They're more likely to have side effects if you take lots of it at doses found in pills, capsules, or gummies. It can cause nausea , diarrhea, or stomach ulcers, especially in high doses or after long-term use. Hu, G. X., Liang, G., Chu, Y., Li, X., Lian, Q. Q., Lin, H., He, Y., Huang, Y., Hardy, D. O., and Ge, R. S. Curcumin derivatives inhibit testicular 17beta-hydroxysteroid dehydrogenase 3. Bioorg.Med.Chem.Lett. 4-15-2010;20(8):2549-2551. View abstract. Rithaporn, T., Monga, M., and Rajasekaran, M. Curcumin: a potential vaginal contraceptive. Contraception 2003;68(3):219-223. View abstract. Ho, S. C., Tsai, T. H., Tsai, P. J., and Lin, C. C. Protective capacities of certain spices against peroxynitrite-mediated biomolecular damage. Food Chem.Toxicol. 2008;46(3):920-928. View abstract.

It’s believed that curcumin might be able to help ease depression and enable antidepressants to work more effectively.Cox KHM, White DJ, Pipingas A, Poorun K, Scholey A. Further evidence of benefits to mood and working memory from lipidated curcumin in healthy older people: A 12-week, double-blind, placebo-controlled, partial replication study. Nutrients. 2020;12(6):1678. doi:10.3390/nu12061678 Fiala, M., Liu, P. T., Espinosa-Jeffrey, A., Rosenthal, M. J., Bernard, G., Ringman, J. M., Sayre, J., Zhang, L., Zaghi, J., Dejbakhsh, S., Chiang, B., Hui, J., Mahanian, M., Baghaee, A., Hong, P., and Cashman, J. Innate immunity and transcription of MGAT-III and Toll-like receptors in Alzheimer's disease patients are improved by bisdemethoxycurcumin. Proc.Natl.Acad.Sci.U.S A 7-31-2007;104(31):12849-12854. View abstract. Curcumin is a compound in turmeric. It's the active ingredient in this popular spice. It also gives it the yellow color.

Hay fever. Taking turmeric by mouth seems to reduce hay fever symptoms such as sneezing, itching, runny nose, and congestion. Agarwal, K. A., Tripathi, C. D., Agarwal, B. B., and Saluja, S. Efficacy of turmeric (curcumin) in pain and postoperative fatigue after laparoscopic cholecystectomy: a double-blind, randomized placebo-controlled study. Surg Endosc. 6-14-2011; View abstract.Chiu, J., Khan, Z. A., Farhangkhoee, H., and Chakrabarti, S. Curcumin prevents diabetes-associated abnormalities in the kidneys by inhibiting p300 and nuclear factor-kappaB. Nutrition 2009;25(9):964-972. View abstract. Funk, J. L., Frye, J. B., Oyarzo, J. N., Kuscuoglu, N., Wilson, J., McCaffrey, G., Stafford, G., Chen, G., Lantz, R. C., Jolad, S. D., Solyom, A. M., Kiela, P. R., and Timmermann, B. N. Efficacy and mechanism of action of turmeric supplements in the treatment of experimental arthritis. Arthritis Rheum. 2006;54(11):3452-3464. View abstract. Turmeric might slow blood clotting. Taking turmeric along with medications that also slow blood clotting might increase the risk of bruising and bleeding.

Hanai, H., Iida, T., Takeuchi, K., Watanabe, F., Maruyama, Y., Andoh, A., Tsujikawa, T., Fujiyama, Y., Mitsuyama, K., Sata, M., Yamada, M., Iwaoka, Y., Kanke, K., Hiraishi, H., Hirayama, K., Arai, H., Yoshii, S., Uchijima, M., Nagata, T., and Koide, Y. Curcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled trial. Clin Gastroenterol.Hepatol. 2006;4(12):1502-1506. View abstract. Kutluay, S. B., Doroghazi, J., Roemer, M. E., and Triezenberg, S. J. Curcumin inhibits herpes simplex virus immediate-early gene expression by a mechanism independent of p300/CBP histone acetyltransferase activity. Virology 4-10-2008;373(2):239-247. View abstract.Be cautious with this combination • Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with TURMERIC Nemavarkar, P., Chourasia, B. K., and Pasupathy, K. Evaluation of radioprotective action of compounds using Saccharomyces cerevisiae. J Environ.Pathol.Toxicol Oncol. 2004;23(2):145-151. View abstract. Santos-Parker JR, Strahler TR, Bassett CJ, Bispham NZ, Chonchol MB, Seals DR. Curcumin supplementation improves vascular endothelial function in healthy middle-aged and older adults by increasing nitric oxide bioavailability and reducing oxidative stress. Aging (Albany NY). 2017;9(1):187-208. doi:10.18632/aging.101149 Korutla, L. and Kumar, R. Inhibitory effect of curcumin on epidermal growth factor receptor kinase activity in A431 cells. Biochim.Biophys.Acta 12-30-1994;1224(3):597-600. View abstract.

Rai, D., Singh, J. K., Roy, N., and Panda, D. Curcumin inhibits FtsZ assembly: an attractive mechanism for its antibacterial activity. Biochem.J 2-15-2008;410(1):147-155. View abstract. Babu, P. S. and Srinivasan, K. Hypolipidemic action of curcumin, the active principle of turmeric (Curcuma longa) in streptozotocin induced diabetic rats. Mol.Cell Biochem. 1997;166(1-2):169-175. View abstract. Nan, B., Yang, H., Yan, S., Lin, P. H., Lumsden, A. B., Yao, Q., and Chen, C. C-reactive protein decreases expression of thrombomodulin and endothelial protein C receptor in human endothelial cells. Surgery 2005;138(2):212-222. View abstract.

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Li H, Sureda A, Devkota HP, et al. Curcumin, the golden spice in treating cardiovascular diseases. Biotechnol Adv. 2020;38:107343. doi:10.1016/j.biotechadv.2019.01.010 Curcumin may also be able to help support gut health, including managing excess gas, abdominal discomfort, and bloating. 12 A 2013 trial by the University of Nottingham found curcumin stimulates the gallbladder to produce bile, an essential substance needed to break down fat in foods. 13